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University of Florida

Publications

Sandra Loesgen, Ph.D.

Recent Publications (2007-Present):

  • Koda, S.A., McCauley, M., Farrell, J.A., Duffy, I. Duffy, F. Loesgen, S., Whilde, J., Duffy. D.J. 2023. A novel eDNA approach for rare species monitoring: application of longread shotgun sequencing to Lynx rufus soil pawprints. Biological Conservation, 287, 110315. doi.org/10.1016/j. biocon.2023.110315
  • Jagels, A., Adpressa, D.A., Kaweesa, E.N.,McCauley, M., Philmus B., Strother, J.A., Loesgen, S. 2023. Metabolomics-Guided Discovery, Isolation, Structure Elucidation, and Bioactivity of Myropeptins C–E from Myrothecium inundatum. J. Nat. Prod. 86(7): 1723–1735.
  • McCauley, M., Goulet, T.L., Jackson, C.R., Loesgen, S. 2023. Systematic review of cnidarian microbiomes reveals insights into the structure, specificity, and fidelity of marine associations. Nat. Commun. 14, 4899, online 08/14/2023. doi.org/10.1038/s41467-023-39876-6
  • Li, Z., Xu, B., Ortega, T., Adpressa, D.A., Ning, W., Wei, X., Liu, J., Tantillo, D.J., Loesgen, S., Rudolf, J.D. 2023. First trans-eunicellane terpene synthase in bacteria. Chem. 3, 698-708. doi.org/10.1016/j.chempr.2022.12.006
  • Kaweesa, E. N., Padhi, A., Davis, G. N., McMillan, R. P., Brown, D. A., Nain, A. S., Loesgen, S. 2022. The natural product mensacarcin combats BRAF mutant and chemoresistant melanoma by affecting cell metabolism and cellular migration. Advances in Cancer Biology –
    Metastasis, 6, 10070. https://doi.org/10.1016/j.adcanc.2022.100070
  • Maruyama, S., Mandelare-Ruiz, P. E., McCauley, M., Peng, W., Cho, B., Wang, J., Mechref,, Y., Loesgen, S., Weis, V. 2022. Heat stress of the algal partner hinders colonization success and alters the algal cell surface glycome in a cnidarian-algal symbiosis. Microbiol. Spec., 10 (3), e01567-22. https://doi.org/10.1128/spectrum.01567-22
  • Robles, A. J., Dai, W., Haldar, S., Ma, H., Anderson, V., Overacker, R. D., Risinger, A. L., Loesgen, S., Houghton, P. J., Cichewicz, R. H., Mooberry. S. L., 2021. Altertoxin II, a highly effective and specific cytotoxin against Ewing sarcoma. Cancers, 13(24), 6176, https://doi.org/10.3390/cancers13246176
  • Khoshbakht, M., Srey, J., Adpressa, D. A., Jagels, A., Loesgen, S. 2021. Precursor-directed biosynthesis of aminofulvenes: new chalanilines from endo phytic fungus Chalara sp. Molecules, 26(15), 4418; https://doi.org/10.3390/molecules26154418
  • Alouane, T., Rimbert, H., Bormann, J., González-Montiel, G. A., Loesgen, S., Schäfer, W., Freitag, M., Langin*, T., Bonhomme L.*. 2021. Comparative Genomics of eight Fusarium graminearum strains with contrasting aggressiveness reveals an expanded open pangenome and extended effector content signatures. Int. J. Mol. Sci., 22, 6257. https://doi.org/10.3390/ijms22126257
  • Khoshbakht, M., Thanaussavadate, B., Zhu, C., Cao, Y., Zakharov, L. N., Loesgen, S., Blakemore, P. R.* 2021. Total Synthesis of Chalaniline B: An Antibiotic Aminoxanthone Isolated from VorinostatTreated Fungus Chalara sp. 6661. J. Org Chem., 86, 7773-7780. DOI:10.1021/acs.joc.1c00528
  • Zhu, C.§, Xu, B.§, Adpressa, D. A.§, Rudolf, J. D.*, Loesgen, S.* 2021. Discovery and biosynthesis of a structurally dynamic antibacterial diterpenoid. Angewandte Chemie, 60, 14163-14170. DOI: 10.1002/anie.202102453R1 and 10.1002/ange.202102453R1
  • Zhu, C., Lew, C. I., Neuhaus, G. F., Adpressa, D. A., Zakharov, L. N., Kaweesa, E. N., Plitzko, B., Loesgen, S. * 2021. Biodiversity, bioactivity, and metabolites of high desert derived Oregonian soil bacteria. Chem. Biodiv.18, e2100046 DOI https://doi.org/10.1002/cbdv.202100046
  • Wu, M.-Y., Mead, M. E., Lee, M.-K., Neuhaus, G. F., Adpressa, D. A., Martien, J. I., Son, Y.-E., Moon H., Amador-Noguez, D., Han, K.-H,. Rokas, A., Loesgen, S., Yu, J.-H., Park, H.-S. 2021. Transcriptomic, protein-DNA interaction, and metabolomic studies of VosA, VelB, and WetA in Aspergillus nidulans asexual spores. mBIO. 12 (1): e03128-20. Doi: 10.1128/mBio.03128-20.
  • Neuhaus, G.F., Loesgen, S.* Antibacterial Drimane Sesquiterpenes from Aspergillus ustus. 2021. J. Nat. Prod., 84, 1, 37-45. Doi: 10.1021/acs.jnatprod.0c00910
  • Wu, M., Mead, M. E., Lee, M., Neuhaus, G. F., Adpressa, D. A., Martien, J. I., Son, Y., Moon, H., Amador-Noguez, D., Han, K., Rokas, A., Loesgen, S., Yu, J., Park, H. 2021. Transcriptomic, protein-DNA interaction, and metabolomic studies of VosA, VelB, and WetA in Aspergillus nidulans asexual spores. Accepted December 21 2020. mBIO Preprint: biorxiv.org/content/10.1101/2020.09.09.290809v1
  • Neuhaus, G.F., Loesgen, S. 2021. Antibacterial Drimane Sesquiterpenes from Aspergillus ustus. Journal of Natural Products. 2021, 84, 1, 37-45. Doi:10.1021/acs.jnatprod.0c00910
  • Overacker, R.D., Plitzko, B., Loesgen, S. 2021. Biolayer interferometry provides a robust method for detecting DNA binding small molecules in microbial extracts. Analytical and Bioanalytical Chemistry, 2021, 413, 1159-1171.
  • Padhi, A., Thomson, A. H., Perry, J. B., Davis, G. N., McMillan, R. P., Loesgen, S., Kaweesa, E. N., Kapania, R., Nain, A. S., and Brown, D. A. 2020. Bioenergetics underlying single-cell migration on aligned nanofiber scaffolds. American Journal of Physiology-Cell Physiology. 318 (3), C476-C485, 3
  • González-Montiel, G. A., Kaweesa, E. N., Feau, N., Hamelin, R. C., Stone, J. K., and Loesgen, S. 2020. Chemical, Bioactivity, and Biosynthetic Screening of Epiphytic Fungus Zasmidium pseudotsugae. Molecules, 25, 2358. DOI:10.3390/molecules25102358
  • Tivey, T. R., Parkinson, J. E., Mandelare, P. E., Adpressa, D. A., Weis, V. M., Loesgen, S. 2020. N-linked surface glycan biosynthesis, composition, inhibition, and function in cnidarian-dinoflagellate symbiosis. Online 25 Jan 2020. DOI: 10.1007/s00248-020-01487-9
  • Padhi, A., Thomson, A. H., Perry, J. B., Davis, G. N., McMillan, R. P., Loesgen, S., Kaweesa, E. N., Kapania, R., Nain, A. S., Brown, D. A. 2019. Bioenergetics underlying single cell migration on aligned nanofiber scaffolds. American Journal of Physiology: Cell Physiology. Online 25 Dec 2019. https://doi.org/10.1152/ajpcell.00221.2019
  • Neuhaus, G. F., Adpressa, D. A., Bruhn, T., Loesgen, S. 2019. Polyketides from marinederived Aspergillus porosus: challenges and opportunities for determining absolute configuration. J. Nat. Prod., 82, 2780-2789. DOI 10.1021/acs.jnatprod.9b00416
  • Adpressa, D. A., Connolly, L. R., Konkel, Z. M., Neuhaus, G. F., Chang, X. L., Pierce, B. R., Smith, K. M., Freitag, M., Loesgen, S. 2019. A metabolomics-guided approach to discover novel Fusarium graminearum metabolites after removal of a repressive histone modification. Fungal Genetics and Biology 132, 103256. DOI: 10.1016/j.fgb.2019.103256
  • Overacker, R. D., Banerjee, S., Neuhaus, G. F., Milicevic Sephton, S., Herrmann, A., Strother, J. A., Brack-Werner, R., Blakemore, P. R., Loesgen. S. 2019. Biological Evaluation of Molecules of the azaBINOL Class as Antiviral Agents: Specific Inhibition of HIV-1 RNase H Activity by 7-Isopropoxy-8-(naphth-1-yl)quinoline“* Bioorganic & Medicinal Chemistry 27, 3595-3604. DOI:10.1016/j.bmc.2019.06.044
  • J. Bormann, C. Heinze, C. Blum, M. Mentges, A. Brockmann, A. Alder, S. K. Landt, B. R. Josephson, D. Indenbirken, M. Spohn, B. Plitzko, S. Loesgen, M. Freitag, W. Schäfer: Expression of a structural protein of the mycovirus FgV-ch9 negatively affects the transcript level of a novel symptom alleviation factor and causes virus-infection like symptoms in Fusarium graminearum. J. Virol. 2018, DOI:10.1128/JVI.00326.18
  • B. Plitzko, S. Loesgen: Measurement of oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) in culture cells for assessment of the energy metabolism. Bio-protocol 2018, 8(10): e2850. DOI: 10.21769/BioProtoc.2850.
  • J. E. Parkinson, T. R. Tivey, P. E. Mandelare, D. A. Adpressa, S. Loesgen, V. M. Weis: Subtle differences in symbiont cell surface glycan profiles do not explain species-specific colonization rates in a model cnidarian-algal symbiosis. Front. Microbiol. 2018, 9, 842. DOI: 10.3389/fmicb.2018.00842
  • P. E. Mandelare, D. A. Adpressa, E. N. Kaweesa, L. N. Zakharov, S. Loesgen: Co-culture of two Developmental Stages of a Marine-derived Aspergillus alliaceus Results in the Production of the Cytotoxic Bianthrone Allianthrone A. J. Nat. Prod. 2018, 18, 1014-1022. DOI:10.1021/acs.jnatprod.8b00024
  • B. Plitzko, E. N. Kaweesa, S. Loesgen: The Natural Product Mensacarcin Induces Mitochondrial Toxicity and Apoptosis in Melanoma Cells. J. Biol. Chem. 2017, 292, 21102-21116. DOI:10.1074/jbc.M116.774836
  • D. A. Adpressa, K. Stalheim, P. J. Proteau, S. Loesgen: Unexpected biotransformation of the HDAC inhibitor vorinostat yields aniline-containing fungal metabolites. ACS Chem. Biol. 2017, DOI:10.1021/acschembio.7b00268
  • S. Shahzad-ul-Hussan, Mallika Sastry, Thomas Lemmin, Cinque Soto, S. Loesgen, Danielle A. Scott, Jack R. Davison, Katheryn Lohith, Robert O'Connor, Peter D. Kwong, C. A. Bewley: NMR structures and characterization of Man-9 free and complexed with HIV-neutralizing agents. ChemBioChem, 2017, 18, 1-9. doi: 10.1002/cbic.201600665.
  • D. A. Adpressa, S. Loesgen: Bioprospecting Chemical Diversity and Bioactivity in a Marine Derived Aspergillus terreus. Chem. Biodivers. 2016, 13, 253-259. DOI: 10.1002/cbdv.201500310.
  • S. Maier, T. Pflüger, S. Loesgen, K. Asmus, E. Brötz, T. Paululat, A. Zeeck, S. Andrade, A. Bechthold: Novel insights into the bioactivity and epoxide formation in mensacarcin by MsnO8. ChemBioChem 2014, 15, 749-756.
  • A. Kachko*, S. Loesgen*, S. Shahzad-ul-Hussan, W. Tan, I. Zubkova, K. Takeda, F. Wells, S. Rubin, C. A. Bewley and M. E. Major: Inhibition of Hepatitis C Virus by the Cyanobacterial Protein MVL: mechanistic differences between the high- mannose specific lectins MVL, CV-N, and GNA. Mol. Pharmaceutics 2013, 10, 4590-4602. DOI: 10.1021/mp400399b.
  • M. Pancera, S. Shahzad-ul-Hussan, N. A. Doria-Rose, K. Dai, J. S. McLellan, R. P. Staupe, Y. Yang, B. Zhang, S. Loesgen, M. N. Amin, L.-X. Wang, D. R. Burton, W. C. Koff, G. J. Nabel, J. R. Mascola, C. A. Bewley, P. D. Kwong: Structure of broadly neutralizing antibody PG16 in complex with HIV-1 gp120 V1/V2 domain reveals complex-type N-glycan recognition. Nat. Struct. Mol. Biol. 2013, 20, 804-813.
  • N. M. Haste, W. Thienphrapa, D. N. Tran, S. Loesgen, P. Sun, S.-J. Nam, P. R. Jensen, W. Fenical, G. Sakoulas, V. Nizet, M. E. Hensler: Activity of the thiopeptide antibiotic nosiheptide against contemporary strains of methicillin-resistant Staphylococcus aureus. J. Antibiot. 2012, 65, 593–598.
  • L. Kaysser, P. Bernhardt, S.-J. Nam, S. Loesgen, J. G. Ruby, P. Skewes-Cox, W. Fenical, B. S. Moore: Merochlorins A–D, cyclic meroterpenoid antibiotics biosynthesized from divergent pathways involving vanadium-dependent chloroperoxidases. J. Am. Chem. 2012, 134, 11988-11991.
  • G. Sakoulas, S.-J. Nam, S. Loesgen, W. Fenical, P. R. Jensen, V. Nizet, M. Hensler: Novel Bacterial Metabolite Merochlorin A Demonstrates in vitro Activity against Multi-Drug Resistant Methicillin-Resistant Staphylococcus aureus. PLoS ONE 7(1): e29439. 2012. doi:10.1371/journal.pone.0029439

    A. Edlund, S. Loesgen, W. Fenical, P. R. Jensen: Geographic Distribution of Secondary Metabolite Genes in the Marine Actinomycete Salinispora arenicola. Appl. Environ. Microbiol. 2011, 77, 5916-5925.
  • S. Loesgen, T. Bruhn, K. Meindl, I. Dix, B. Schulz, A. Zeeck, G. Bringmann: (+)-Flavipucine, the Missing Member of the Pyridione Epoxide Family of Fungal Antibiotics. Eur. J. Org. Chem. 2011, 26, 5156-5162.
  • B. Schulz, S. Draeger, T. E. dela Cruz, J. Rheinheimer, K. Siems, S. Loesgen, J. Bitzer, O. Schloerke, A. Zeeck, I. Kock, H. Hussein, J. Dai, K. Krohn: Screening strategies for obtaining novel, biologically active, fungal secondary metabolites from marine habitats. Botanica Marina 2008, 51, 219-234.
  • S. Lösgen, J. Magull, B. Schulz, S. Draeger, A. Zeeck: Isofusidienols, Novel Chromone-3-oxepines Produced by the Endophytic Fungus Chalara sp. Eur. J. Org. Chem. 2008, 698-703.
  • S. Lösgen, O. Schlörke, K. Meindl, R. Herbst-Irmer, A. Zeeck: Structure and Biosynthesis of Chaetocyclinones, New Polyketides Produced by an Endosymbiotic Fungus. Eur. J. Org. Chem. 2007, 2191-2196.
  • S. Lösgen: Isolation and Structure Elucidation of Secondary Metabolites of Fungi associated with marine Algae and Semisynthetic Studies on the Cytotoxic Polyketide Mensacarcin. Book in German. Sierke Verlag Göttingen Göttingen 2007 (ISBN 3-940333-18-6).