Recent Publications (2007-Present):
Kaweesa, E. N., Padhi, A., Davis, G. N., McMillan, R. P., Brown, D. A., Nain, A. S., Loesgen, S. 2022. The natural product mensacarcin combats BRAF mutant and chemoresistant melanoma by affecting cell metabolism and cellular migration. Advances in Cancer Biology –
Metastasis, 6, 10070. https://doi.org/10.1016/j.adcanc.2022.100070
Maruyama, S., Mandelare-Ruiz, P. E., McCauley, M., Peng, W., Cho, B., Wang, J., Mechref,, Y., Loesgen, S., Weis, V. 2022. Heat stress of the algal partner hinders colonization success and alters the algal cell surface glycome in a cnidarian-algal symbiosis. Microbiol. Spec., 10 (3), e01567-22. https://doi.org/10.1128/spectrum.01567-22
Robles, A. J., Dai, W., Haldar, S., Ma, H., Anderson, V., Overacker, R. D., Risinger, A. L., Loesgen, S., Houghton, P. J., Cichewicz, R. H., Mooberry. S. L., 2021. Altertoxin II, a highly effective and specific cytotoxin against Ewing sarcoma. Cancers, 13(24), 6176, https://doi.org/10.3390/cancers13246176
Khoshbakht, M., Srey, J., Adpressa, D. A., Jagels, A., Loesgen, S. 2021. Precursor-directed biosynthesis of aminofulvenes: new chalanilines from endo phytic fungus Chalara sp. Molecules, 26(15), 4418; https://doi.org/10.3390/molecules26154418
Alouane, T., Rimbert, H., Bormann, J., González-Montiel, G. A., Loesgen, S., Schäfer, W., Freitag, M., Langin*, T., Bonhomme L.*. 2021. Comparative Genomics of eight Fusarium graminearum strains with contrasting aggressiveness reveals an expanded open pangenome and extended effector content signatures. Int. J. Mol. Sci., 22, 6257. https://doi.org/10.3390/ijms22126257
Khoshbakht, M., Thanaussavadate, B., Zhu, C., Cao, Y., Zakharov, L. N., Loesgen, S., Blakemore, P. R.* 2021. Total Synthesis of Chalaniline B: An Antibiotic Aminoxanthone Isolated from VorinostatTreated Fungus Chalara sp. 6661. J. Org Chem., 86, 7773-7780. DOI:10.1021/acs.joc.1c00528
Zhu, C.§, Xu, B.§, Adpressa, D. A.§, Rudolf, J. D.*, Loesgen, S.* 2021. Discovery and biosynthesis of a structurally dynamic antibacterial diterpenoid. Angewandte Chemie, 60, 14163-14170. DOI: 10.1002/anie.202102453R1 and 10.1002/ange.202102453R1
Zhu, C., Lew, C. I., Neuhaus, G. F., Adpressa, D. A., Zakharov, L. N., Kaweesa, E. N., Plitzko, B., Loesgen, S. * 2021. Biodiversity, bioactivity, and metabolites of high desert derived Oregonian soil bacteria. Chem. Biodiv.18, e2100046 DOI https://doi.org/10.1002/cbdv.202100046
Wu, M.-Y., Mead, M. E., Lee, M.-K., Neuhaus, G. F., Adpressa, D. A., Martien, J. I., Son, Y.-E., Moon H., Amador-Noguez, D., Han, K.-H,. Rokas, A., Loesgen, S., Yu, J.-H., Park, H.-S. 2021. Transcriptomic, protein-DNA interaction, and metabolomic studies of VosA, VelB, and WetA in Aspergillus nidulans asexual spores. mBIO. 12 (1): e03128-20. Doi: 10.1128/mBio.03128-20.
Neuhaus, G.F., Loesgen, S.* Antibacterial Drimane Sesquiterpenes from Aspergillus ustus. 2021. J. Nat. Prod., 84, 1, 37-45. Doi: 10.1021/acs.jnatprod.0c00910
Wu, M., Mead, M. E., Lee, M., Neuhaus, G. F., Adpressa, D. A., Martien, J. I., Son, Y., Moon, H., Amador-Noguez, D., Han, K., Rokas, A., Loesgen, S., Yu, J., Park, H. 2021. Transcriptomic, protein-DNA interaction, and metabolomic studies of VosA, VelB, and WetA in Aspergillus nidulans asexual spores. Accepted December 21 2020. mBIO Preprint: biorxiv.org/content/10.1101/2020.09.09.290809v1
Neuhaus, G.F., Loesgen, S. 2021. Antibacterial Drimane Sesquiterpenes from Aspergillus ustus. Journal of Natural Products. 2021, 84, 1, 37-45. Doi:10.1021/acs.jnatprod.0c00910
Overacker, R.D., Plitzko, B., Loesgen, S. 2021. Biolayer interferometry provides a robust method for detecting DNA binding small molecules in microbial extracts. Analytical and Bioanalytical Chemistry, 2021, 413, 1159-1171.
Padhi, A., Thomson, A. H., Perry, J. B., Davis, G. N., McMillan, R. P., Loesgen, S., Kaweesa, E. N., Kapania, R., Nain, A. S., and Brown, D. A. 2020. Bioenergetics underlying single-cell migration on aligned nanofiber scaffolds. American Journal of Physiology-Cell Physiology. 318 (3), C476-C485, 3
González-Montiel, G. A., Kaweesa, E. N., Feau, N., Hamelin, R. C., Stone, J. K., and Loesgen, S. 2020. Chemical, Bioactivity, and Biosynthetic Screening of Epiphytic Fungus Zasmidium pseudotsugae. Molecules, 25, 2358. DOI:10.3390/molecules25102358
Tivey, T. R., Parkinson, J. E., Mandelare, P. E., Adpressa, D. A., Weis, V. M., Loesgen, S. 2020. N-linked surface glycan biosynthesis, composition, inhibition, and function in cnidarian-dinoflagellate symbiosis. Online 25 Jan 2020. DOI: 10.1007/s00248-020-01487-9
Padhi, A., Thomson, A. H., Perry, J. B., Davis, G. N., McMillan, R. P., Loesgen, S., Kaweesa, E. N., Kapania, R., Nain, A. S., Brown, D. A. 2019. Bioenergetics underlying single cell migration on aligned nanofiber scaffolds. American Journal of Physiology: Cell Physiology. Online 25 Dec 2019. https://doi.org/10.1152/ajpcell.00221.2019
Neuhaus, G. F., Adpressa, D. A., Bruhn, T., Loesgen, S. 2019. Polyketides from marinederived Aspergillus porosus: challenges and opportunities for determining absolute configuration. J. Nat. Prod., 82, 2780-2789. DOI 10.1021/acs.jnatprod.9b00416
Adpressa, D. A., Connolly, L. R., Konkel, Z. M., Neuhaus, G. F., Chang, X. L., Pierce, B. R., Smith, K. M., Freitag, M., Loesgen, S. 2019. A metabolomics-guided approach to discover novel Fusarium graminearum metabolites after removal of a repressive histone modification. Fungal Genetics and Biology 132, 103256. DOI: 10.1016/j.fgb.2019.103256
Overacker, R. D., Banerjee, S., Neuhaus, G. F., Milicevic Sephton, S., Herrmann, A., Strother, J. A., Brack-Werner, R., Blakemore, P. R., Loesgen. S. 2019. Biological Evaluation of Molecules of the azaBINOL Class as Antiviral Agents: Specific Inhibition of HIV-1 RNase H Activity by 7-Isopropoxy-8-(naphth-1-yl)quinoline“* Bioorganic & Medicinal Chemistry 27, 3595-3604. DOI:10.1016/j.bmc.2019.06.044
J. Bormann, C. Heinze, C. Blum, M. Mentges, A. Brockmann, A. Alder, S. K. Landt, B. R. Josephson, D. Indenbirken, M. Spohn, B. Plitzko, S. Loesgen, M. Freitag, W. Schäfer: Expression of a structural protein of the mycovirus FgV-ch9 negatively affects the transcript level of a novel symptom alleviation factor and causes virus-infection like symptoms in Fusarium graminearum. J. Virol. 2018, DOI:10.1128/JVI.00326.18
B. Plitzko, S. Loesgen: Measurement of oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) in culture cells for assessment of the energy metabolism. Bio-protocol 2018, 8(10): e2850. DOI: 10.21769/BioProtoc.2850.
J. E. Parkinson, T. R. Tivey, P. E. Mandelare, D. A. Adpressa, S. Loesgen, V. M. Weis: Subtle differences in symbiont cell surface glycan profiles do not explain species-specific colonization rates in a model cnidarian-algal symbiosis. Front. Microbiol. 2018, 9, 842. DOI: 10.3389/fmicb.2018.00842
P. E. Mandelare, D. A. Adpressa, E. N. Kaweesa, L. N. Zakharov, S. Loesgen: Co-culture of two Developmental Stages of a Marine-derived Aspergillus alliaceus Results in the Production of the Cytotoxic Bianthrone Allianthrone A. J. Nat. Prod. 2018, 18, 1014-1022. DOI:10.1021/acs.jnatprod.8b00024
B. Plitzko, E. N. Kaweesa, S. Loesgen: The Natural Product Mensacarcin Induces Mitochondrial Toxicity and Apoptosis in Melanoma Cells. J. Biol. Chem. 2017, 292, 21102-21116. DOI:10.1074/jbc.M116.774836
D. A. Adpressa, K. Stalheim, P. J. Proteau, S. Loesgen: Unexpected biotransformation of the HDAC inhibitor vorinostat yields aniline-containing fungal metabolites. ACS Chem. Biol. 2017, DOI:10.1021/acschembio.7b00268
S. Shahzad-ul-Hussan, Mallika Sastry, Thomas Lemmin, Cinque Soto, S. Loesgen, Danielle A. Scott, Jack R. Davison, Katheryn Lohith, Robert O'Connor, Peter D. Kwong, C. A. Bewley: NMR structures and characterization of Man-9 free and complexed with HIV-neutralizing agents. ChemBioChem, 2017, 18, 1-9. doi: 10.1002/cbic.201600665.
D. A. Adpressa, S. Loesgen: Bioprospecting Chemical Diversity and Bioactivity in a Marine Derived Aspergillus terreus. Chem. Biodivers. 2016, 13, 253-259. DOI: 10.1002/cbdv.201500310.
S. Maier, T. Pflüger, S. Loesgen, K. Asmus, E. Brötz, T. Paululat, A. Zeeck, S. Andrade, A. Bechthold: Novel insights into the bioactivity and epoxide formation in mensacarcin by MsnO8. ChemBioChem 2014, 15, 749-756.
A. Kachko*, S. Loesgen*, S. Shahzad-ul-Hussan, W. Tan, I. Zubkova, K. Takeda, F. Wells, S. Rubin, C. A. Bewley and M. E. Major: Inhibition of Hepatitis C Virus by the Cyanobacterial Protein MVL: mechanistic differences between the high- mannose specific lectins MVL, CV-N, and GNA. Mol. Pharmaceutics 2013, 10, 4590-4602. DOI: 10.1021/mp400399b.
M. Pancera, S. Shahzad-ul-Hussan, N. A. Doria-Rose, K. Dai, J. S. McLellan, R. P. Staupe, Y. Yang, B. Zhang, S. Loesgen, M. N. Amin, L.-X. Wang, D. R. Burton, W. C. Koff, G. J. Nabel, J. R. Mascola, C. A. Bewley, P. D. Kwong: Structure of broadly neutralizing antibody PG16 in complex with HIV-1 gp120 V1/V2 domain reveals complex-type N-glycan recognition. Nat. Struct. Mol. Biol. 2013, 20, 804-813.
N. M. Haste, W. Thienphrapa, D. N. Tran, S. Loesgen, P. Sun, S.-J. Nam, P. R. Jensen, W. Fenical, G. Sakoulas, V. Nizet, M. E. Hensler: Activity of the thiopeptide antibiotic nosiheptide against contemporary strains of methicillin-resistant Staphylococcus aureus. J. Antibiot. 2012, 65, 593–598.
L. Kaysser, P. Bernhardt, S.-J. Nam, S. Loesgen, J. G. Ruby, P. Skewes-Cox, W. Fenical, B. S. Moore: Merochlorins A–D, cyclic meroterpenoid antibiotics biosynthesized from divergent pathways involving vanadium-dependent chloroperoxidases. J. Am. Chem. 2012, 134, 11988-11991.
G. Sakoulas, S.-J. Nam, S. Loesgen, W. Fenical, P. R. Jensen, V. Nizet, M. Hensler: Novel Bacterial Metabolite Merochlorin A Demonstrates in vitro Activity against Multi-Drug Resistant Methicillin-Resistant Staphylococcus aureus. PLoS ONE 7(1): e29439. 2012. doi:10.1371/journal.pone.0029439
A. Edlund, S. Loesgen, W. Fenical, P. R. Jensen: Geographic Distribution of Secondary Metabolite Genes in the Marine Actinomycete Salinispora arenicola. Appl. Environ. Microbiol. 2011, 77, 5916-5925.
S. Loesgen, T. Bruhn, K. Meindl, I. Dix, B. Schulz, A. Zeeck, G. Bringmann: (+)-Flavipucine, the Missing Member of the Pyridione Epoxide Family of Fungal Antibiotics. Eur. J. Org. Chem. 2011, 26, 5156-5162.
B. Schulz, S. Draeger, T. E. dela Cruz, J. Rheinheimer, K. Siems, S. Loesgen, J. Bitzer, O. Schloerke, A. Zeeck, I. Kock, H. Hussein, J. Dai, K. Krohn: Screening strategies for obtaining novel, biologically active, fungal secondary metabolites from marine habitats. Botanica Marina 2008, 51, 219-234.
S. Lösgen, J. Magull, B. Schulz, S. Draeger, A. Zeeck: Isofusidienols, Novel Chromone-3-oxepines Produced by the Endophytic Fungus Chalara sp. Eur. J. Org. Chem. 2008, 698-703.
S. Lösgen, O. Schlörke, K. Meindl, R. Herbst-Irmer, A. Zeeck: Structure and Biosynthesis of Chaetocyclinones, New Polyketides Produced by an Endosymbiotic Fungus. Eur. J. Org. Chem. 2007, 2191-2196.
S. Lösgen: Isolation and Structure Elucidation of Secondary Metabolites of Fungi associated with marine Algae and Semisynthetic Studies on the Cytotoxic Polyketide Mensacarcin. Book in German. Sierke Verlag Göttingen Göttingen 2007 (ISBN 3-940333-18-6).